Tunisia's health minister Abdel-Raouf El-Sherif resigned on Saturday after 11 babies mysteriously died within 24 hours in a hospital in the capital, state news agency TAP said.
The health ministry and state prosecutors have launched investigations into the cause of the babies' death which was likely due to a blood infection, it said.
Tunisians have complained about a decline of state services since the overthrow of Zine El-Abidine Ben Ali in 2011 which has brought a democratic transition but also thrown the country into an economic crisis.
Government critics say the public sector is rife with corruption.