The coronavirus has infected hundreds of people in Chinese prisons, authorities said on Friday, contributing to a jump in reported cases beyond the epicenter in Hubei province, including 100 more in South Korea.
U.S. stock indexes fell after data showed U.S. business activity stalled in February and the rise in new coronavirus cases sent investors scrambling for safer assets such as gold, which jumped to its highest in seven years.
A total of 234 infections among Chinese prisoners outside Hubei ended 16 straight days of declines in new mainland cases.
Another 271 cases were reported in prisons in Hubei - where the virus first emerged in December in its now locked-down capital, Wuhan - though provincial officials did not say when they had been diagnosed.
State television quoted Communist Party rulers as saying the outbreak had not yet peaked, and more than 30 cases in a hospital in Beijing highlighted a sharp jump in the tally there.
Total cases in the Chinese capital of the coronavirus - known as COVID-19 - were at 396 with four deaths, out of an official mainland toll of 75,400 cases and 2,236 deaths.
U.S. activity in both the manufacturing and services sectors stalled as companies have grown increasingly concerned about the coronavirus, a survey of purchasing managers showed Friday.
The IHS Markit flash services sector Purchasing Managers' Index dropped to 49.4 this month, the lowest since October 2013
and signalling that a sector accounting for roughly two-thirds of the U.S. economy was in contraction for the first time since 2016.
Data also showed Japan's factory activity suffered its steepest contraction in seven years in February, underlining the risk of a recession there as the impact of the outbreak spreads. Asian and European stocks also fell.
With finance leaders from the Group of 20 major economies set to discuss risks to the world economy in Saudi Arabia at the weekend, the International Monetary Fund said it was too early to tell what impact the virus would have on global growth.
But the outbreak may curb demand for oil in China and other Asian countries, depressing prices to as low as $57 a barrel and clouding growth prospects across the Middle East, the Institute of International Finance said.
The World Health Organization warned that the window of opportunity to contain the international spread of the epidemic was closing after cases were reported in Iran and Lebanon.
The virus has emerged in 26 countries and territories outside mainland China, killing 11 people, according to a Reuters tally.
"This outbreak could go in any direction," WHO chief Tedros Adhanom Ghebreyesus said in Geneva. "If we do well, we can avert any serious crisis, but if we squander the opportunity then we will have a serious problem on our hands."
Chinese Vice Science and Technology Minister Xu Nanping said China's earliest vaccine would be submitted for clinical trials around late April. That timetable is in line with research in other countries, and a World Health Organization estimate of a vaccine reaching the market in about 18 months.
As international authorities seek to stop the virus from becoming a global pandemic, public health officials are hoping for signs that the arrival of warmer weather in the northern hemisphere might slow its spread.
PUBLIC GATHERINGS
The spike in cases in two jails outside Hubei - in the northern province of Shandong and Zhejiang in the east - made up most of the 258 newly confirmed Chinese infections outside the epicenter province on Friday.
Authorities said officials deemed responsible for the outbreaks had been fired and the government had sent a team to investigate the Shandong episode, media reported.
Hubei, adding to confusion about numbers, doubled the number of new cases it reported on Wednesday to 775 from 349. Provincial authorities said they would add back some cases to their tally, after they adjusted their methodology to count only cases that were detected with genetic tests, rather than with CT scans.
South Korea is the latest hot spot with 100 new cases taking its total to 204, most in Daegu, a city of 2.5 million, where scores were infected in what authorities called a "super-spreading event" at a church, traced to an infected 61-year-old woman who attended services.
South Korean officials designated Daegu and neighboring Cheongdo county as special care zones where additional medical staff and isolation facilities will be deployed. Malls, restaurants and streets in the city were largely empty with the mayor calling the outbreak an "unprecedented crisis".
Another center of infection has been the Diamond Princess cruise ship held under quarantine in Japan since Feb. 3.
Japan reported the deaths of two elderly passengers on Thursday, the first fatalities from aboard the ship where more than 630 cases account for the biggest cluster of infection outside China.
In the Iranian city of Qom, state TV showed voters in the parliamentary election wearing surgical masks.
The country confirmed 13 new cases, two of whom had died. Most have been in Qom, a Shiite Muslim holy city where health officials on Thursday called for all religious gatherings to be suspended.
Ukraine's health minister joined evacuees from China for two weeks' quarantine in a sanatorium on Friday in a show of solidarity after fears over the possible spread of the coronavirus led to clashes between protesters and police.